Profile at a glance
Paracetamol is a painkiller, more
technically described as a non-opioid analgesic. As a painkiller, it's
similar in strength to aspirin, but does not have the anti-inflammatory
action of aspirin.
Paracetamol is thought to work by blocking
the production of chemicals, known as prostaglandins, which are involved
in pain transmission. But, unlike aspirin and nonsteroidal
anti-inflammatory drugs (NSAIDs) such as ibuprofen, it blocks them in
the brain not at the source of pain.
Paracetamol can be taken in tablet,
capsule or liquid form, and is also available as suppositories.
Paracetamol can be bought without a prescription from pharmacies and (in
packs of up to 16 tablets) from other shops. It's vital that you always
take it in the doses recommended on the packet. The recommend dose for
adults is 500mg to 1000mg every 4-6 hours (one to two standard tablets),
up to a maximum of 4000mg (8 tablets) in 24 hours.
Side effects are rare with paracetamol
when it is taken at the recommended doses. Skin rashes, blood disorders
and acute inflammation of the pancreas have occasionally occurred in
people taking the drug on a regular basis for a long time. One advantage
of paracetamol over aspirin and NSAIDs is that it doesn't irritate the
stomach or causing it to bleed, potential Side effects of aspirin and
NSAIDs.
Paracetamol is often contained in branded
pain relieving products (see list below) and cough and cold remedies.
These also often contain other painkillers such as codeine and other
ingredients such as caffeine or a decongestant.
The early commercial production of
paracetamol relied on the nitration of phenol to p-nitrophenol with a
reduction step to produce p-aminophenol followed by acetylation with
acetic anhydride.
In the UK, sales of over-the-counter
Paracetamol in pharmacies are restricted to packs of 32 tablets per
customer per occasion (only 16 tablets in non-pharmacy stores). In
Ireland, the limits are 24 and 12 tablets respectively.
Liquid preparations of paracetamol are expensive
Tablets are a much cheaper form of paracetamol than
liquid preparations, and some brands of paracetamol tablets are very much
cheaper than others (the brands listed in the Schedule of Pharmaceutical
Benefits tend to be less expensive). |
General
- Tylenol
- Drug Metabolic Interactions
- Paracetamol Background Information
- Pharmaceutical Solid Acetaminophen Doped
Thermal Behavior
- Supercritical Fluids
Products and Tablet Formulations
- Acetaminophen D.C Grade
- Paracetamol Powder
BP2002/USP26
- Calpol Six Plus Sugar Free Suspension
- Paracetamol Products
- Paracetamol 500
- Tablet Formulations Compression and Mechanical
Properties
- Pregelatinization of Starch Binders
- Comparison of Granule and Tablet Properties
Technology
- Crystallization
- Various Paracetamol Manufacturing Technologies
- Process Analytical Technology Applications
- Pharmaceutical Technology Report
- Crystallo-co-Agglomeration Technique
- Contract Manufacturing
- Pharmaceutical Patents
- US Patent:6,028,222
Equipment, Raw Material and Formulation
Manufacturers and Suppliers
- Paracetamol Cone blender Machine Manufacturers
and Suppliers in India
- Granulator Machinery Manufacturers and
Suppliers
- Powders/Granules Manufacturers and
Suppliers-India
- Powder Manufacturers-China
- Mass Mixer Machinery Manufacturers and
Suppliers
- Tray Drying Oven Machine Manufacturers and
Suppliers-India
- Pharmaceutical Packaging Machinery
Suppliers-China
- Tabletting Machine Manufacturers and
Suppliers-India
- Strip Packing Machine Suppliers-India
- TOSC International-Pharmaceutical Formulations
Manufacturers
- Trade Leads
- Paracetamol Powder Buyers
| Projects, Reports and Reviews - Paracetamol Project Brief
- Project of 12500tons/Year of Paracetamol Raw Medicine
- Granules India Report
- Oral Liquid Paracetamol-Ireland
- Project Know how Reports
- Paracetamol Orthorhombic Polymorph Article
- Nonprescription Analgesics Review
- Paracetamol-Induced Oxidative Stress in Rats
Marketing and Cost Estimation
- Pharmaceutical Sector-India
- Anti-Dumping Investigations Concerning Imports
of Paracetamol from China and Taiwan
- Paracetamol Market Reports
- Masters Marketing-Price List
- Drug Costs
- Pacific Pharma Generics - Price List
- CNS Market Outlook to 2010
Company Overview
- PFI Compresso Brochure
- Drugs and Pharmaceuticals
Industry Highlights
- Formulation Challenges
- Power Handling
- Röhm Pharma Polymers
- Global Channel
- Rochem International
Guidelines and Regulatory Issues - PRODIGY Quick Reference Guide
- Acetaminophen Overdose
- Safe Acetaminophen (Tylenol) Use
- A Dancer's Guide To Pain Relief
- Acetaminophen Poisoning
- Alka-Seltzer XS
- DCGI
- Paracetamol Regulations
|
|
